試題詳解

83. Sterol regulatory element-binding protein (SREBP) controls the gene expression of cholesterol biosynthesis. What happens when there is the presence of a high cellular concentration of cholesterol?
(A) It increases the proteolytic cleavage and releases SREBP into the nucleus.
(B) SREBP is hold in the Golgi apparatus in a complex with SREBP-cleavage-activating protein (SCAP) to produce a regulatory domain fragment.
(C) It activates SREBP by inducing the conformational change for cholesterol biosynthesis.
(D) It stabilizes the SCAP-SREBP complex by the anchoring of insulin-induced gene protein (Insig).
(E) SREBP acts as a corepressor of RXR-LXR dimer to terminate the gene expression of cholesterol biosynthesis.