84. Which of the following statements about the inhibition of enzyme activity is FALSE?
(A) Transition state analogs can be used as competitive inhibitor.
(B) Irreversible inhibition can be analyzed using Michaelis-Menten equation.
(C) Increasing substrate concentration can counteract the effect of competitive inhibitor.
(D) An uncompetitive inhibition does not affect the slope of the Lineweaver-Burk plot.
(E) The irreversible inhibitor is covalently linked with the catalytic residue at the active site of the enzyme.

80. Which of the following BEST explains the "wobble" hypothesis proposed by Francis Crick? (A) The genetic code is degenerate in that most amino acids have more than one codon. (B) The genetic code is ambiguous in that each codon can specify more than one amino acid. (C) The anticodon can pair with any part of the corresponding codon. (D) The 5'-base of the anticodon can make non Watson-Crick hydrogen bonds with several different bases at the 3'-position of the codon. (E) Inosine can pair up with C, G, or U.

81. Phospholipids show asymmetric distribution on membrane of erythrocytes. Which of the following phospholipids prefer to distribute on the outer leaflet of erythrocyte membrane? ① phosphatidylcholine； ② phosphatidylserine； ③ phosphatidylinositol； ④ sphingomyelin； ⑤ phosphatidylethanolamine (A) ①,② (B) ①,③ (C) ①,④ (D) ②,③ (E) ②,⑤

82. Mammalian phosphofructokinase, the major flux-controlling enzyme of glycolysis, is regulated by ① allosteric activator, fructose 2, 6-bisphosphate； ② allosteric inhibitor, ATP； ③ allosteric activator, AMP； ④ allosteric inhibitor, ADP； ⑤ allosteric activator, Citrate (A) ①,②,③ (B) ①,③,④ (C) ①,②,⑤ (D) ①,③,⑤ (E) ①,④,⑤

83. Misfolding of protein causes a broad range of disease. Which of the following human diseases linked to misfolding of proteins are CORRECT? ① Alzheimer’s disease, β-Amyloid peptide ； ② Creutzfeldt-Jakob disease, Prion protein ； ③ Cystic fibrosis, Superoxide dismutase I； ④ Hungtington’s disease, α-Synuclein； ⑤ Familial amyloidotic polyneuropathy, Transthyretin. (A) ①,②,③ (B) ①,②,④ (C) ②,③,⑤ (D) ③,④,⑤ (E) ①,②,⑤

85. Which of the following enzymes are involved in the purine salvage pathways? ① GMP synthetase； ② Adenine phosphoribosyl transferase； ③ Purine nucleoside phosphorylase； ④ Hypoxanthine-guanine phosphoribosyltransferase； ⑤ Adenylosuccinate lyase (A) ①,② (B) ②,③ (C) ③,④,⑤ (D) ②,④ (E) ②,③,④

86. Which of the following statements for cholesterol are CORRECT? ① Cholesterol is a precursor of lanosterol. ② Cholesterol is a component of cell membrane in human erythrocyte. ③ Cholesterol is a precursor of bile acids. ④ Cholesterol is terpene-based lipid. ⑤ Cholesterol reduces the transition temperature of phospholipids in cell membrane. (A) ①,②,③ (B) ①,③,⑤ (C) ①,②,④ (D) ②,③,④ (E) ②,④,⑤

複選題87. Which of the following statements is CORRECT in DNA repair? (A) AlkB is involved in base-excision repair. (B) AP endonuclease is involved in mismatch repair. (C) ABC excinuclease is involved in nucleotide-excision repair. (D) DNA photolyase is involved in direct repair. (E) Dam methylase is involved in methyl-directed repair.

88. A peptide is digested by chymotrypsin, and the resulting peptides are shown as following: GlyAsn； Asp-Met-Leu-Phe； Leu-Lys-Trp； Met-Arg-Ala-Tyr. The C-terminal amino acid of the starting peptide (the one cleaved with chymotrypsin) is (A) Asn (B) Phe (C) Trp (D) Tyr (E) Gly

複選題89. Which of the followings inhibit fatty acid synthesis: ① malonyl CoA； ② glucagon； ③ citrate； ④ phosphorylated acetyl-CoA carboxylase (AB) ①,②,③ (AC) ①,②,④ (AD) ①,③,④ (AE) ②,③,④ (BC) ①,②,③,④ (BD)一律送分

90. Which of the following statements about pentose phosphate pathway is FALSE? (A) The major pathway is to produce five-carbon sugars. (B) The major products are two molecules of NADPH and one molecule of ribulose-5- phosphate. (C) Oxidation of glucose 6-phosphate to 6-phosphoglucono-δ-lactone is the first reaction. (D) It provides ribose-5-phosphate for nucleotide biosynthesis. (E) It occurs exclusively in the mitochondria.