試題詳解

89.65 歲男性十年前接受腎臟移植，近一年肌肝酸值從 1.2 mg/dL 逐漸上升至 1.8 mg/dL。排除其他急性問題後腎臟切片結果顯示”replacement of myocytes in afferent arterioles with beads of hyaline that bulge into the adventitia, striped interstitial fibrosis and tubular atrophy”，研判應和長期藥物使用 有關，下列何種藥物可能性最高？
(A) Prednisolone
(B) Calcineurin inhibitor
(C) mTOR inhibitor
(D) Mycophenolate mofetil
(E) Basiliximab