2. If proofreading by the editing of DNA polymerase is defective, which mutation may occur? (A) Translocation. (B) Inversion. (C) Single nucleotide substitution. (D) Large deletion.

1. The famous movies star, Angelina Jolie, has her breast and ovaries removed because she inherits a mutant version of BRCA1. Which biological process is affected in BRCA1 mutant so that she has high risk of cancer? (A) DNA synthesis. (B) RNA synthesis. (C) DNA repair. (D) protein synthesis.