3. Please describe the principle of Statins medicines on decreasing serum cholesterol.

1. Please translate the following research abstract into Mandarin.        Cumulative evidence indicates that excessive consumption of calories from saturated fat contributes to the development of Alzheimer's disease (AD). Here, we assess the triggering and progression of AD pathology induced by a high-fat diet (HFD), and the effects of resveratrol, a polyphenol found in common dietary sources with multiple neuroprotective activities. Over 16 weeks, male wild type (WT) and AD transgenic 5XFAD mice were fed a control diet, HFD (60% kcal from fat), or HFD supplemented with 0.1% resveratrol. Resveratrol protected against HFD- induced memory loss in WT mice and prevented memory loss in 5XFAD mice. Resveratrol also reduced the amyloid burden worsen by HFD in 5XFAD, and protected against HFD-induced tau pathology in both WT and 5XFAD strains. At the mechanistic level, resveratrol inhibited the HFD- increased amyloidogenic processing of the amyloid precursor protein in both strains； it also restored abnormal high levels in the proteolytic activity of the ubiquitin-proteasome system induced by HFD, suggesting the presence of a compensatory mechanism to reduce the accumulation of abnormal proteins. Thus, our data suggest that resveratrol can correct the harmful effects of HFD in the brain and may be a potential therapeutic agent against obesity-related disorders and AD pathology.

2. Please draft the title of above-mentioned abstract in English or Mandarin.

1. Please describe three biological processes to contribute proteome complexity from limited genome.

2. Please describe inducible lac operon.

3. Please describe the possible mechanisms that radiation sterilization to be applied in microbial control in food.

V. Please translate the following paragraph into Mandarin. Many enzymes require metal ions for maximal activity. If the enzyme binds the metal very tightly or requires the metal ion to maintain its stable, native state, it is referred to as a metalloenzyme. Enzymes that bind metal ions more weakly, perhaps only during the catalytic cycle, are referred to as metal activated. One role for metals in metal-activated enzymes and metalloenzymes is to act as electrophilic catalysts, stabilizing the increased electron density or negative charge that can develop during reactions.

一、 請舉例說明修飾澱粉有哪些以及在食品工業上的應用案例。

二、 將咖啡粉、糖粉和熱水一次加入，接著使用攪拌棒在相同方向持續攪拌400次，咖啡顏色會漸漸從深轉淺，顆粒消失且呈現細緻的柔滑質地。請問400次咖啡如何造 就滑順及持久的奶泡?

1. Please write down a subtitle for this paragraph.

2. Please tell how tyrosine (abundance and position) exert influence on the antioxidant activity.

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