61. Ribonucleotide reductase catalyzes the reduction of ribonucleotides to deoxyribonucleotides. Which of the following cofactors are essential for the activity of ribonucleotide reductase? ① NADPH； ② Thioredoxin； ③ NADH； ④ Glutaredoxin； ⑤ Tetrahydrofolate
(A) ①,②,⑤
(B) ①,②,④
(C) ①,③,⑤
(D) ②,③,⑤
(E) ②,③,④

57. Which is NOT a function of the pigment epithelium in retina? (A) absorption of scattered light (B) phagocytizing shed outer discs (C) isomerize the all-trans retinal to the 11-cis form (D) delivery of nutrients to the photoreceptors (E) creating the dark current of the photoreceptors

複選題58. The form and function of nephrons in vertebrate kidney have a different adaptation to meet their requirements for osmoregulation. Which one is CORRECT? (AB) Freshwater fishes conserve salt in their proximal tubules and excrete large volumes of dilute urine. (AC) Amphibians conserve water on land by reabsorbing water from collecting duct. (AD) Mammals that inhabit in fresh water have relatively long loops of Henle. (AE) Birds have shorter loops of Hendle. (BC) Most reptiles excrete uric acid by juxtamedullary nephron. (BD)一律送分

59. Which organ or tissue is differentiated from mesoderm? (A) epidermis of skin (B) nervous system (C) adrenal medulla (D) dermis of skin (E) thymus

60. ______ are NOT derived from myeloid stem cell. (A) Basophils (B) Erythrocytes (C) Lymphocytes (D) Monocytes (E) Platelets

複選題62. In eukaryotic matured mRNA, which one of the following statements is FALSE? (AB) Both 5’ and 3’ ends contain a free 3-OH group on ribose. (AC) Intron is removed in the matured RNA. (AD) Poly( A ) tail is added to 3’ end in matured RNA. (AE) Methylation can be found on 5’ end. (BC) Splicing needs snRNAs. (BD)一律送分

63. A cell that is unable to synthesize or obtain tetrahydrofolate would probably be deficient in the biosynthesis of ______. (A) dGMP (B) dCMP (C) dAMP (D) dTMP (E) dUMP

64. Pompe disease is a glycogen storage disease caused by defect in ______. (A) glycogen phosphorylase (B) lysosomal α-1,4-glucosidase (C) glycogen branching enzyme (D) glucose-6-phosphatase (E) phosphorylase kinase

65. Which of the following statements about allosteric regulation are CORRECT? ① Substrate is a heterotropic allosteric modulator. ② Allosteric regulation can increase or decrease the catalytic activity of enzymes. ③Allosteric enzymes typically have oligomeric structure. ④ The activity of some allosteric enzymes is regulated by feedback inhibition. ⑤ Allosteric modulators cannot induce conformational change of allosteric enzymes. (A) ①,②,③ (B) ①,②,④ (C) ①,③,④ (D) ①,③,⑤ (E) ②,③,④

66. Which of the following statements about ribozyme are CORRECT? ① Peptidyl transferase is a ribozyme. ②Aminoacyl-tRNA synthetase is a ribozyme. ③ The substrate of ribozyme is RNA. ④ Hammerhead ribozyme is involved in trans-splicing reaction. ⑤ RNase P is a ribozyme. (A) ①,②,③ (B) ①,③,④ (C) ①,④,⑤ (D) ①,③,⑤ (E) ②,④,⑤

67. Which of the following statements about microRNAs (miRNAs) are CORRECT? ① miRNAs originate from exogenous dsRNA. ② miRNAs form a perfect complementary to its target mRNA. ③ Some miRNAs can functionally inhibit mRNA translation. ④ Some miRNAs can promote mRNA decay. ⑤ miRNAs are transcribed by RNA polymerase III. (A) ①,⑤ (B) ②,③ (C) ③,④ (D) ②,④ (E) ③,⑤