76.女性賀爾蒙的變化，容易導致牙周組織明顯的改變，下列敘述何者錯誤？
(A)月經時期會增加牙齦發炎並伴隨牙齦溝液增加
(B)停經婦女用動情素（estrogen）治療骨質疏鬆症（osteoporosis）可以增加骨頭密度
(C)懷孕時期動情素和黃體素（progesterone）升高，增加牙齦上皮角質化，和牙齦血管通透性及 牙齦溝液
(D)懷孕婦女體內的黃體素上升，造成適合Prevotella intermedia 生長的牙周環境

(C)懷孕時期動情素和黃體素（progesterone）升高，增加牙齦上皮角質化，和牙齦血管通透性及 牙齦溝液

--會減少牙齦上皮角質化 

【出處】Lindie 5th p.312~315 【Hint】 The increase in severity of gingivitis during pregnancy has been partly attributed to the increased circulatory levels of progesterone and its effects on the capillary vessels. Elevated progesterone levels in pregnancy enhance capillary permeability and dilatation, resulting in increased gingival exudate. The effects of progesterone in stimulating prostaglandin synthesis can account for some of the vascular changes. The elevated levels of estrogen and progesterone in pregnancy affect the degree of keratinization of the gingival epithelium and alter the connective tissue ground substance. The decreased keratinization of the gingivae, together with an increase in epithelial glycogen, are thought to result in decreased effectiveness of the epithelial barrier in pregnant women.Hormonal factors that affect the epithelium and increase vascular permeability can contribute to an exaggerated response to bacterial plaque during pregnancy.