78 靜脈注射 250 mg的藥物,其血中濃度變化以Cp = 14.0e -1.4t + 2.0e -0.4t 表示,其中Cp是指t小時的藥物血中濃度(µg/mL)。該藥物若改以 200 mg/hr的輸注速率連續靜脈輸注,請問預期的穩定血中濃度為多少mg/L?
(A) 12
(B) 22
(C) 32
(D) 42
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統計: A(355), B(36), C(135), D(15), E(0) #414960
統計: A(355), B(36), C(135), D(15), E(0) #414960
詳解 (共 3 筆)
#820871
AUC = 14/1.4+2/0.4 = 10+5 = 15
C = K AUC K = C / AUC = > KVd = D / AUC = 250 / 15
Css = R / KVd = R / (250 / 15) = 200 / 250 x 15 = 12
10
1
#1604042
D / AUC = CL
Css = R / CL
5
0