8. The "2018 Nobel Prize in Chemistry" was awarded to scientists who pioneered directed evolution. Which of the following statement about directed evolution is NOT correct? (A) It mimics natural evolution and directs protein engineering toward a user-defined goal. (B) It involves iterative rounds mutagenesis, selection and amplification. (C) High fidelity DNA polymerases are used for random mutagenesis in vitro. (D) The fidelity of the Taq DNA polymerase can be modulated by alteration of the composition of the reaction buffer. (E) DNA shuffling is another powerful method for directed evolution, which generates diversity by recombination.