Contraindications: diffuse peritonitis with hemodynamics compromise and uncontrolled bleeding disorders.
If there is suspicion of gallbladder cancer, open cholecystectomy should be performed.
Relative contraindications: previous abdominal surgery, cirrhosis with portal hypertension, sever cardiopulmonary disease, active cholangitis, morbid obesity
LC can be performed safely during any trimester of pregnancy.