47.下列何種材質遇水後可形成凝膠,而具控釋能力?
(A)alginic acid
(B)polylactic acid
(C)ethylene-vinyl acetate copolymer
(D)polyglycolic acid
統計: A(3221), B(103), C(1337), D(156), E(0) #3065612
詳解 (共 10 筆)
<alginic acid相關國考題>
42 製劑中使用賦形劑 Alginic acid 之主要目的,下列何者除外?
(A) 錠劑之結合劑
(B) 錠劑之崩散劑
(C) 製劑中之增稠劑
(D) 錠劑之潤滑劑
54. 下列對藻酸(alginic acid)之敘述何者正確?
(A) 10~20%濃度作為稠厚劑
(B) 為黑色至紅色之顆粒
(C) 在水中能膨脹200~300倍
(D) 加入鈣鹽降低其水溶液黏度
55 Morphine sulfate 緩釋栓劑之基劑中含有下列何項成分,使其藥物的釋出可延長至數小時?
(A) Ascorbic acid
(B) Sodium stearate
(C) Alginic acid
(D) Glycerol
22.長效型嗎啡栓劑的基劑中,可加入何種成分用以延長藥物釋放時間?
(A)海藻酸
(B)鋅明膠
(C)聚乙二醇
(D)甲基纖維素
19.以不同成分製備的水性凝膠劑(gels),有關其黏度變化之敘述,下列何者錯誤?
(A)鈣鹽會降低alginic acid凝膠之黏度
(B)氫氧化鈉會增加carbomer凝膠之黏度
(C)溫度對colloidal silicon dioxide凝膠之黏度無太大影響
(D)高濃度電解質會增加methylcellulose凝膠之黏度
18.下列敘述何者正確?
(A)在carbomer 凝膠中加入酒精,可增加其黏稠度
(B)carboxymethylcellulose 製成之凝膠,在 pH > 10 時會增加其黏稠度
(C)alginic acid 添加鈣鹽,可因產生交聯而增加黏稠度
(D)以colloidal silicon dioxide 製成之凝膠,其黏稠度不受 pH 值影響
40.Pilocarpine Ocusert® 製劑中之reservoir(貯藥庫)是由 pilocarpine 與下列何者所組成?
(A)methylcellulose
(B)gellan gum
(C)alginic acid
(D)Carbopol 940
整理自前人
海藻酸Alginic acid及其鈉鹽
加入鈣鹽發生交連,增加黏度
遇水膨脹(Swelling)的效果最佳:在水中能膨脹200~300倍
⭐️用途:
凝膠化劑 gelling agent(遇水形成凝膠,有控釋能力)benzoic acid 不是凝膠化劑
1-5% 增稠劑Viscosity increasing agent
錠劑之黏合劑Tablet binder
崩散劑Tablet Disintegrant
海藻酸鈉適合生物鹼,可以當pilocarpine 的 reservior
◇Ocusert 眼用長效製劑
1. 1-5%作為膠將增稠劑(pH2.5~3)
2. 鈣鹽增加黏度
3.水中膨脹200-300倍
22.長效型嗎啡栓劑的基劑中,可加入何種成分用以延長藥物釋放時間?
polyglycolic acid :醫用聚乙醇酸可吸收縫合線
取自維基
(C) ethylene-vinyl acetate copolymer
EVA is also used in biomedical engineering applications as a drug-delivery device. The polymer is dissolved in an organic solvent (such as dichloromethane). Powdered drug and filler (typically an inert sugar) are added to the liquid solution and rapidly mixed to obtain a homogeneous mixture. The drug-filler-polymer mixture is then cast into a mold at −80 °C and freeze-dried until solid. These devices are used in drug delivery research to slowly release a compound. The polymer does not biodegrade within the body, but is quite inert and causes little or no reaction following implantation.