49.一位55歲男性，妻子抱怨經常被他半夜睡覺時每隔20到90秒不等的一陣陣腿抖動吵醒，這種腿抖動以腳掌及 大拇趾dorsiflexion為主，每次抖動約0.5 到5秒，他辯稱自己完全不知道，但自覺睡眠品質差，白天工作時常 打瞌睡。關於此一病人之病症，下列敘述何者錯誤？
(A)最可能診斷為睡眠陣發性肢體動作症（periodic limb movements in sleep）
(B)腦電圖（EEG）上可發現在腿抖動的對側大腦額葉運動區，伴隨有20到90秒一次之癲癇放電（epileptic discharges）現象
(C)常伴隨有不寧腿症候群（restless legs syndrome）
(D)dopamine agonist 或 anticonvulsants對部分病人有效

Restless legs syndrome (RLS), also called Willis-Ekbom disease (WED), is a common sleep-related movement disorder characterized by an often unpleasant or uncomfortable urge to move the legs that occurs during periods of inactivity, particularly in the evenings, and is transiently relieved by movement. During sleep, most patients with RLS have characteristic limb movements, called periodic limb movements of sleep (PLMS), which may or may not be associated with arousal from sleep.

The most consistently implicated central nervous system (CNS) alteration in patients with RLS is reduced central iron stores; alterations in dopaminergic systems, circadian physiology, thalamic function, and other neurotransmitters such as glutamate and gamma-aminobutyric acid (GABA) have also been implicated.